In circulatory disease, a clumping of red blood cells hinders blood flow and becreases oxygen absorption due to reduced surface area. There is a decrease in red blood cell flexibility which prevents them travelling down the tiniest capillaries, and blood viscosity increases. With Ozone therapy, clumping is reduced or eliminated and flexibility is restored, along with oxygen carrying abiltiy. Oxygenation of the tissues increases as the arterial partial pressure increases, and viscosity decreases. Ozone also oxidizes the plaque in arteries allowing the removal of the breakdown products, unclogging vessels.