IgE vs. IgG Mediated Allergens
Classical skin testing for allergies such as skin-scratch testing, only measures IgE-mediated reactions and provides no information concerning delayed IgG hypersensitivity reactions. Assessment of relative IgG antibody levels to a multitude of foods using sensitive Enzyme-Linked Immunosorbent Assay (ELISA) technology identifies those foods against which the patient is producing antibodies. Measuring both relative IgE and IgG antibody levels provides an invaluable starting point for dietary intervention. The key differences between IgE and IgG mediated allergies are summarized below: IgE Mediated Allergies Immediate onset (within minutes) Circulating half life of 1-2 days Permanent allergies Stimulates histamine release Includes foods, inhalants & molds IgG Mediated Allergies Delayed onset (4-72 hours) Circulating half life of 21 days Temporary allergies Stimulates histamine release Includes foods, herbs & spices.